Quick answer: the liposomal supplements with the most research behind them are glutathione and vitamin C. For magnesium, B12, vitamin D and most newer liposomal products, regular forms are usually just as useful for much less money. Whatever you buy in Canada, check for an NPN, compare price per serving and avoid products that promise to treat or cure disease.
How we wrote this guide: Liposomal.ca is independent. We do not accept payment for inclusion. Products below are examples available through Canadian retailers and brand websites in 2026, chosen to show the range of formats and prices. Always check the current label, price and NPN before buying.
Our five-step checklist
- NPN: natural health products legally sold in Canada carry an eight-digit Natural Product Number. Verify it in Health Canada’s Licensed Natural Health Products Database (LNHPD).
- Real dose: look for milligrams of the actual nutrient per serving, not the weight of the “liposomal blend”.
- Evidence: is there a human study showing the liposomal form of this nutrient is absorbed better? (See Liposomal vs Regular.)
- Ingredients: phospholipid source (sunflower or soy), sweeteners, flavours and allergens.
- Price per serving: divide the price by the servings at the dose you will actually take.
Liposomal vitamin C
Evidence: moderate. Small human studies show higher blood levels than unencapsulated vitamin C. Most useful for people who take larger doses and get stomach upset from regular tablets. Full guide: Liposomal Vitamin C Benefits.
| Example | Format | Typical Canadian price |
|---|---|---|
| Natural Factors Liposomal Vitamin C (Canadian brand) | Softgels, 500 mg each, 2 per serving | About $18 for 60 softgels (about $0.60 per 1,000 mg serving) on iHerb Canada |
| LivOn Labs Lypo-Spheric Vitamin C | Liquid gel sachets, 30 per box | Premium; sold by Canadian retailers such as Vitasave |
| Cymbiotika Liposomal Vitamin C | Gel sachets, 1-month supply | About $81 one-time or $73 by subscription on cymbiotika.ca |
Our take: softgels give the best value; sachets suit people who want a higher single dose and do not mind the taste and price.
Liposomal glutathione
Evidence: the strongest case for liposomal delivery, because regular oral glutathione is poorly absorbed in some studies. Studies used 500 to 1,000 mg a day. Full guide: Best Liposomal Glutathione in Canada.
| Example | Format | Notes |
|---|---|---|
| Cymbiotika Liposomal Glutathione | Gel sachets | About $100 to $115 per month |
| Codeage Liposomal Glutathione | Capsules, 250 mg each | Sold on iHerb Canada |
| Natural Factors Glutathione LipoMicel Matrix | Softgels | Micellar rather than liposomal delivery |
Liposomal magnesium
Evidence: weak for the liposomal form specifically. Magnesium citrate and glycinate are already reasonably well absorbed and cost far less. Adults should not exceed 350 mg a day of magnesium from supplements unless a doctor advises it, because more can cause diarrhea. Our take: most people are better served by a regular magnesium glycinate or citrate.
Liposomal vitamin B12
Evidence: limited. B12 is absorbed well from food and standard supplements in people with normal digestion. People with absorption problems need medical treatment, often injections. Our take: a regular B12 tablet or sublingual is enough for most people, including vegans who need a reliable source.
Liposomal vitamin D
Evidence: limited advantage. Vitamin D is fat-soluble and is absorbed well from a regular softgel or drops taken with a meal. Health Canada sets the adult upper limit at 4,000 IU a day. Our take: regular vitamin D drops or softgels are the value choice, especially in Canadian winters.
Liposomal curcumin
Evidence: curcumin from turmeric is very poorly absorbed in its standard form, so enhanced forms (liposomal, micellar, combined with piperine and others) make sense. Head-to-head comparisons between these enhanced forms are limited. Curcumin can interact with blood thinners; ask a pharmacist.
Liposomal NAD+ and other newer products
Evidence: early. NAD+ products, along with liposomal ashwagandha, L-theanine and creatine, are heavily marketed for energy and healthy ageing, but there is little independent human research on the liposomal versions. Some premium NAD+ sachets cost about $100 or more per month. Our take: treat these as experimental and be sceptical of big claims.
Summary table
| Nutrient | Liposomal worth it? | Cheaper alternative |
|---|---|---|
| Glutathione | Yes, best evidence | NAC (ask a pharmacist) |
| Vitamin C | Sometimes, at high doses | Regular 250 to 500 mg tablet; fruit and vegetables |
| Curcumin | An enhanced form is worth it | Other enhanced curcumin forms |
| Magnesium | Rarely | Magnesium glycinate or citrate |
| Vitamin B12 | Rarely | Regular tablet or sublingual |
| Vitamin D | Rarely | Drops or softgels with a meal |
| NAD+, ashwagandha, L-theanine | Unproven | Discuss with a health professional |
Where to buy liposomal supplements in Canada
- Pharmacies and health food stores: you can ask a pharmacist about interactions on the spot.
- Canadian online retailers such as Well.ca and Vitasave, and the Canadian site of iHerb.
- Brand websites with Canadian shipping, such as cymbiotika.ca.
Be careful with marketplace listings shipped from overseas. Many have no NPN, may not contain what the label says and may be seized at the border.
Frequently asked questions
Are liposomal supplements regulated in Canada?
Yes. They are natural health products under Health Canada’s Natural Health Products Regulations and need a product licence (NPN) to be sold legally.
Is a more expensive liposomal product always better?
No. Price reflects format, branding and marketing as much as quality. Compare the actual dose, NPN and testing information.
Can I take several liposomal supplements together?
Check total intake against upper limits, especially for vitamin C, vitamin D and magnesium, and ask a pharmacist if you take medication.
Sources
- Health Canada. Natural Health Products Regulations; Licensed Natural Health Products Database; Dietary Reference Intakes.
- National Institutes of Health, Office of Dietary Supplements. Fact sheets on vitamin C, magnesium, vitamin B12 and vitamin D.
- Sinha R, et al. European Journal of Clinical Nutrition, 2018.
- Davis JL, et al. Nutrition and Metabolic Insights, 2016.
Disclosure: some links on Liposomal.ca may become affiliate links, which means we may earn a commission at no extra cost to you. See our affiliate disclosure. This article is for general information only and is not medical advice. See our medical disclaimer.
